Ragon Institute
May 4, 2021
by: Rachel Leeson. Image credit: Christinelmiller, wikicommons Ragon scientists discover elite controllers have myeloid dendritic cells that display characteristics of trained innate immune cells Most discussions around immunity center around the adaptive immune response, the part of the immune system made up of antibodies and T cells that learn to fight specific pathogens […]
Apr 29, 2021
Single-cell analysis of autopsy samples from COVID-19 patients shows how the lungs repeatedly tried, and failed, to repair themselves. By Stephanie M. McPherson, Broad Institute Image credit: Domenic Abbondanza Image description: Researchers profiled lung tissue from deceased COVID-19 patients and zoomed in on key regions and structures of interest. A group of scientists from several […]
Mar 25, 2021
by: Julie Cunningham, MGH. Image credit: Galit Alter/Cell Pregnant women show robust immune response to COVID vaccines, pass antibodies to newborns In the largest study of its kind to date, researchers at Massachusetts General Hospital, Brigham and Women’s Hospital, and the Ragon Institute of Mass General, MIT, and Harvard have found the new […]
Mar 16, 2021 Ragon Culture
Image courtesy of: Cambridge Science Festival The Ragon Institute, as part of its educational and community-building initiatives, is participating in Cambridge Science Festival 2021, a virtual event held throughout the month of April. The Science Festival is a celebration showcasing the leading edge in science, technology, engineering, art, and math. Based out of the MIT Museum, the festival, […]
Mar 12, 2021
by: Rachel Leeson. Image courtesy of: iSO-FORM LLC Researchers at the Ragon Institute of Mass General, MIT, and Harvard and at Massachusetts General Hospital find that neutralizing antibodies raised by COVID-19 vaccines are not as effective at neutralizing some new, circulating SARS-CoV-2 variants. SARS-CoV-2, the virus that causes COVID-19, has mutated throughout the […]
Mar 10, 2021 Ragon Culture
image credit: Lisa Ferdinando, Office of the Secretary of Defense As part of its commitment to science education, the Ragon Institute had the unique opportunity of working with the Cambridge Public Library to bring COVID-19 information straight from researchers to the public. Ragon Director Bruce Walker, MD; Harvard postdoctoral fellow Zuri Sullivan, PhD; and Josefine […]
Feb 23, 2021 Ragon Culture
The Ragon Institute of Mass General, MIT, and Harvard is collaborating with the Cambridge Public Library on “Vaccines and the COVID-19 Pandemic: A Primer for the Public,” as part of the Cambridge Public Library’s Our Path Forward Series. The event, which features Bruce Walker, MD, Director of the Ragon, and Zuri Sullivan, PhD, will take […]
Feb 22, 2021
by: Rachel Leeson. Image credit: MRI Scan, courtesy of the NIH. A stroke, like any traumatic event in the body, triggers an immune response and understanding this immune response is critical to improve patient outcomes and nominate new therapeutics. But immune responses in the brain are difficult to study in humans, because the brain is […]
Feb 18, 2021
by: Rachel Leeson; image credit: Illustration from Anatomy & Physiology, Connexions Web site Researchers at the Ragon Institute of Mass General, MIT, and Harvard and Massachusetts General Hospital show that levels of specific antibodies developed in the immune response may influence COVID-19 outcomes in both children and adults. COVID-19, the source of the current pandemic, may […]
Feb 15, 2021
by: Rachel Leeson. Image credit: antibody opsonization, Maher33 While PCR testing has been used widely for COVID-19 diagnosis, it only provides information on who is currently infected. Antibody testing can tell who has been previously exposed to SARS-CoV-2, the virus that causes COVID-19, a metric that is essential for tracking spread across a population. […]
Feb 10, 2021
by: Rachel Leeson. image credit: HIV on macrophages, Reconfirming the Traditional Model of HIV Particle Assembly. Gross L, PLoS Biology Vol. 4/12/2006, e445. Most HIV-infected cells can be readily killed by immune cells, which recognize and attack infected cells that are making copies of the virus. Ragon postdoc Kiera Clayton, however, found that HIV-infected […]
Feb 3, 2021 Ragon Culture
Ragon Associate director Facundo Batista, PhD, has accepted an appointment as Chief Editor of The EMBO Journal. Batista, who is also a professor at Harvard Medical School, succeeds Bernd Pulverer, PhD, Head of Scientific Publishing at EMBO. “I am delighted to serve the wider scientific community by joining The EMBO Journal as Chief Editor,” says Batista. “It is […]
Jan 14, 2021
by: Rachel Leeson One of the most common metaphors used in science is the explanation of DNA as like an alphabet, with the bases of DNA like letters. Ragon Member Bryan Bryson, PhD, along with MIT professor Bonnie Berger, took this metaphor to a whole new level, using natural language processing to predict mutations […]
Dec 22, 2020
image courtesy of the authors Ragon scientists discover dendritic cells help regulate IL-6, a key component in cytokine storms. The cytokine IL-6 is a major driver of immune response and, when present in high levels in the blood, can help drive cytokine storms, such as seen in severe COVID-19 disease. Recently, Ragon scientists […]
Dec 17, 2020
By Claudia Lopez Lloreda, Broad Institute The nervous and immune systems have long been thought to be separate entities in the body, but new research has uncovered a direct cellular interaction between the two. Scientists from Harvard Medical School, the Broad Institute of MIT and Harvard, MIT, and the Ragon Institute of Mass General, […]
Dec 15, 2020
image credit: broadly neutralizing B12 antibody (green) with an HIV target (red), courtesy of the NIH Image Library and NIAID Ragon scientists find that neutralizing antibody potency predicts severe or fatal COVID-19. Understanding the body’s immune response to SARS-CoV-2, the virus that causes COVID-19, is key to developing effective treatments and long-lasting vaccines. Of […]