Ragon Institute
May 30, 2025 Features
Researchers at the Ragon Institute have made a significant discovery about how antibodies can directly enhance the body’s ability to fight Mycobacterium tuberculosis (Mtb), the bacteria responsible for tuberculosis (TB). Despite decades of research, TB remains one of the deadliest infectious diseases worldwide, with about 10 million new cases and 1.6 million deaths annually. Currently, […]
Apr 24, 2025 Research Highlights
A recent study published in Science Translational Medicine, co-authored by Ragon Institute faculty members Azza Idris, MD, PhD, and Galit Alter, PhD, demonstrates that engineering antibodies to enhance Fc receptor binding can significantly improve their effectiveness against malaria infection. The researchers tested modified versions of human monoclonal antibodies, CIS43LS and L9LS, which target a protein […]
Apr 22, 2025 Research Highlights
A new study co-authored by Shiv Pillai, MD PhD, reveals two distinct populations of human memory B cells that persist long-term after vaccination or infection. Published in Cell Reports, the research identifies canonical memory B cells, originating from germinal centers, and a newly characterized durable population known as DN1 B cells. The study found that DN1 […]
Apr 4, 2025 Features
A healthy vaginal environment dominated by Lactobacillus crispatus is associated with a lower risk of HIV acquisition among women. However, only a fraction of women worldwide, and even fewer in Africa, have vaginal microbiomes dominated by Lactobacillus crispatus. Now, a groundbreaking study led by Drs. Anke Hemmerling and Craig Cohen from UCSF’s Department of Obstetrics, Gynecology & Reproductive […]
Feb 27, 2025 Research Highlights
A new study published in Science by researchers from the Ragon Institute, NIH/NIAID, and the University of Chicago reveals a critical function of the immune system: how regulatory T cells (Tregs) selectively suppress autoimmune reactions while allowing protective responses against infections. The immune system must constantly balance two opposing forces—attacking harmful invaders while preventing damage to healthy […]
Jan 29, 2025 Research Highlights
An exciting collaboration between the Ragon Institute and the Jameel Clinic at MIT has achieved a significant milestone in leveraging artificial intelligence (AI) to aid the development of T cell vaccine candidates. Ragon faculty member Gaurav Gaiha, MD, DPhil, and MIT Professor Regina Barzilay, PhD, AI lead of the Jameel Clinic for AI and Health, […]
Jan 27, 2025 Research Highlights
A recent study published in Nature Immunology, co-authored by Ragon Institute faculty member Alex K. Shalek, PhD, provides critical insights into how SARS-CoV-2 variants and vaccination status shape immune responses in the nasal mucosa. This research, which utilized advanced single-cell RNA sequencing (scRNA-seq) approaches, explores how cellular responses in the human nasal cavity differ across […]
Oct 1, 2024 Research Highlights
Researchers at the Ragon Institute of Mass General Brigham, MIT, and Harvard have uncovered critical insights into how aging impairs the immune system’s ability to fight cancer. A study led by the Ringel Lab at the Ragon Institute and published in Cancer Immunology Research shows that as the body ages a type of immune cells called CD8+ T cells, essential for […]
Sep 24, 2024 Research Highlights
Researchers from the Shalek Lab at the Ragon Institute of Mass General Brigham, MIT, and Harvard, in collaboration with the Broad Institute, have uncovered key insights into how prior Mycobacterium tuberculosis (Mtb) infection primes the immune system for enhanced protection against reinfection. This study, published in Immunity on August 30, used a non-human primate model to demonstrate that […]