GUEST AUTHOR: Nick Kolev

The lab of the Ragon Institute faculty member Hernandez Moura Silva, PhD, recently published a review in Science Immunology regarding resident tissue macrophages (RTMs), shedding light on their multifaceted roles in organ health. 

RTMs, integral components found abundantly across various organs, have traditionally been recognized for their immune defense functions. However, this review highlights their contributions extend far beyond immune response.

The manuscript explores the specialized activities of RTMs tailored to sustain critical homeostatic functions within organs. It explored how the distinct microenvironments of different organs influence the development and functions of RTMs and discusses the implications of dysregulation, which can lead to various diseases. 

Furthermore, the manuscript underscores the importance of recognizing both the commonalities and unique characteristics among RTM subsets across different organs, aiming to consolidate recent classifications into a cohesive understanding of their roles in maintaining tissue homeostasis.