Hernandez Moura Silva

Hernandez Moura Silva, PhD

Principal Investigator


Core Member

Ragon Institute of MGH, MIT and Harvard

Assistant Professor

Department of Biology at MIT

Contact


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Immune-mediated circuits supporting organ functions

Research Overview

The Moura Silva lab seeks to understand how the immune system supports organ physiology and metabolism to unveil new approaches to treat human diseases.

Research at Moura Silva Lab is directed to the understanding of fundamental immune-related pathways that modulate organ and tissue physiology. By utilizing an innovative, multidisciplinary and intersectional approach, our lab seeks to unveil cellular and molecular circuits used by Macrophages and other immune cells that support the maintenance of organ and tissue homeostasis.  The ultimate goal of our research program is to develop new strategies to tune these immune mediated molecular pathways in health and disease, leading to the development of much-needed therapeutic approaches for human diseases.

Recognition and Media

CAPES Thesis Award - Brazil, 2012

About

Dr. Moura Silva received a BSc in Biology and a M.Sc. in Molecular Biology at University of Brasilia-Brazil. He performed his Ph.D. in immunology at University of São Paulo School of Medicine in Brazil and completed his postdoctoral training in immunology at the NYU Lagone Health’s Skirball Institute of Biomolecular Medicine.

Selected Publications

CX3CR1+ monocytes modulate learning and learning-dependent dendritic spine remodeling via TNF-α

Garré, JM, Silva, HM, Lafaille, JJ, Yang, G

2017. Nat Med 23, 714-722

Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges

Silva, HM, Báfica, A, Rodrigues-Luiz, GF, Chi, J, Santos, PDA, Reis, BS, Hoytema van Konijnenburg, DP, Crane, A, Arifa, RDN, Martin, P et al.

2019. J Exp Med 216, 786-806

Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease

Lee, JY, Hall, JA, Kroehling, L, Wu, L, Najar, T, Nguyen, HH, Lin, WY, Yeung, ST, Silva, HM, Li, D et al.

2020. Cell 180, 79-91.e16

Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy

Wu, L, Hollinshead, KER, Hao, Y, Au, C, Kroehling, L, Ng, C, Lin, WY, Li, D, Silva, HM, Shin, J et al.

2020. Cell 182, 641-654.e20

P2X7 receptor inhibition ameliorates dendritic spine pathology and social behavioral deficits in Rett syndrome mice

Garré, JM, Silva, HM, Lafaille, JJ, Yang, G

2020. Nat Commun 11, 1784

Leukocyte Heterogeneity in Adipose Tissue, Including in Obesity

Weinstock, A, Moura Silva, H, Moore, KJ, Schmidt, AM, Fisher, EA

2020. Circ Res 126, 1590-1612

c-MAF dependent perivascular macrophages regulate diet induced metabolic syndrome

Silva, H.M., Kitoko, J.Z., Queiroz, C.P., Kroehling, L., Matheis, F., Yang, K.L., Ren-Fielding, C., Littman, D.R., Bozza, M.T., Mucida, D., and Lafaille, J.J.

2021. bioRxiv.

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