Principal Investigator
Core Member
Ragon Institute of Mass General, MIT, and Harvard
Assistant Professor
Department of Biology at MIT
400 TS
The Moura Silva lab seeks to understand how the immune system supports organ physiology and metabolism to unveil new approaches to treat human diseases.
Research at Moura Silva Lab is directed to the understanding of fundamental immune-related pathways that modulate organ and tissue physiology. By utilizing an innovative, multidisciplinary and intersectional approach, our lab seeks to unveil cellular and molecular circuits used by Macrophages and other immune cells that support the maintenance of organ and tissue homeostasis. The ultimate goal of our research program is to develop new strategies to tune these immune mediated molecular pathways in health and disease, leading to the development of much-needed therapeutic approaches for human diseases.
CAPES Thesis Award - Brazil, 2012
Dr. Moura Silva received a BSc in Biology and a M.Sc. in Molecular Biology at University of Brasilia-Brazil. He performed his Ph.D. in immunology at University of São Paulo School of Medicine in Brazil and completed his postdoctoral training in immunology at the NYU Lagone Health’s Skirball Institute of Biomolecular Medicine.
Garré, JM, Silva, HM, Lafaille, JJ, Yang, G
2017. Nat Med 23, 714-722
Silva, HM, Báfica, A, Rodrigues-Luiz, GF, Chi, J, Santos, PDA, Reis, BS, Hoytema van Konijnenburg, DP, Crane, A, Arifa, RDN, Martin, P et al.
2019. J Exp Med 216, 786-806
Lee, JY, Hall, JA, Kroehling, L, Wu, L, Najar, T, Nguyen, HH, Lin, WY, Yeung, ST, Silva, HM, Li, D et al.
2020. Cell 180, 79-91.e16
Wu, L, Hollinshead, KER, Hao, Y, Au, C, Kroehling, L, Ng, C, Lin, WY, Li, D, Silva, HM, Shin, J et al.
2020. Cell 182, 641-654.e20
Garré, JM, Silva, HM, Lafaille, JJ, Yang, G
2020. Nat Commun 11, 1784
Weinstock, A, Moura Silva, H, Moore, KJ, Schmidt, AM, Fisher, EA
2020. Circ Res 126, 1590-1612
Silva, H.M., Kitoko, J.Z., Queiroz, C.P., Kroehling, L., Matheis, F., Yang, K.L., Ren-Fielding, C., Littman, D.R., Bozza, M.T., Mucida, D., and Lafaille, J.J.
Science Immunology • 1 Oct 2021 • Vol 6, Issue 64 • DOI: 10.1126/sciimmunol.abg7506 PubMed Read on Journal Site
Ilya Andreev
Graduate Student
Beatriz Burger
Graduate Student
Anika Hutton
Graduate Student
Brandon Sullivan
Research Technician I
Jill Wisnewski
Graduate Student
Jia Zhao
Graduate Student
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The Ragon’s research creates knowledge from our collaborative, cross-disciplinary approach, breaking down the silos of academia.