Pregnant women show robust immune response to COVID vaccines, pass antibodies to newborns. In the largest study of its kind to date, researchers at Massachusetts General Hospital, Brigham and Women’s Hospital, and the Ragon Institute of Mass General, MIT, and Harvard have found the new mRNA COVID-?? vaccines to be highly effective in producing antibodies against the SARS-CoV-? virus in pregnant and lactating women. They also demonstrated the vaccines confer protective immunity to newborns through breastmilk and the placenta. The study, published in the American Journal of Obstetrics and Gynecology (AJOG), looked at ??? women of reproductive age (?? pregnant, ?? lactating and ?? non-pregnant), all of whom received one of the two new mRNA vaccines: Pfizer/BioNTech or Moderna. The vaccine-induced titers ‒ or antibody levels ‒ were equivalent in all three groups. Reassuringly, side effects after vaccination were rare and comparable across the study participants.

“This news of excellent vaccine efficacy is very encouraging for pregnant and breastfeeding women, who were left out of the initial COVID-?? vaccine trials,” says Andrea Edlow, MD, MSc, a Maternal-Fetal Medicine specialist at MGH, director of the Edlow Lab in the Vincent Center for Reproductive Biology and co-senior author of the new study. “Filling in the information gaps with real data is key ‒ especially for our pregnant patients who are at greater risk for complications from COVID-??. This study also highlights how eager pregnant and lactating individuals are to participate in research.” According to the Centers for Disease Control and Prevention, individuals who are pregnant are more likely to become severely ill with COVID-??, require hospitalization, intensive care or ventilation ‒ and may be at
increased risk for adverse pregnancy outcomes. The team also compared vaccination-induced antibody levels
to those induced by natural infection with COVID-?? in pregnancy, and found significantly higher levels of
antibodies from vaccination.

Vaccine-generated antibodies were also present in all umbilical cord blood and breastmilk samples taken from the study, showing the transfer of antibodies from mothers to newborns. “We now have clear evidence the COVID vaccines can induce immunity that will protect infants,” says Galit Alter, PhD, core member of the Ragon Institute and co-senior author of the study. “We hope this study will catalyze vaccine developers to recognize the importance of studying pregnant and lactating individuals, and include them in trials. The potential for rational vaccine design to drive improved outcomes for mothers and infants is limitless, but developers must realize that pregnancy is a distinct immunological state, where two lives can be saved simultaneously with a powerful vaccine. We look forward to studying all vaccine platforms in pregnancy as they become available.”

The study was also able to provide insight into potential differences between the immune response elicited by
the Pfizer vaccine compared to the Moderna vaccine, finding the levels of mucosal (IgA) antibodies were higher
after the second dose of Moderna compared to the second dose of Pfizer. “This finding is important for all individuals, since SARS-CoV-? is acquired through mucosal surfaces like the nose, mouth and eyes,” says Kathryn Gray, MD, PhD, an obstetrician at Brigham and Women’s Hospital and a first author of the paper. “But it also holds special importance for pregnant and lactating women because IgA is a key antibody present in breastmilk.”

Gray’s co-first authors on the study are Evan Bordt, PhD, of MGH and Caroline Atyeo of the Ragon Institute.

Funding for the study included grants from the National Institute of Child Health and Human Development
(NICHD), the Gates Foundation, the Massachusetts Consortium on Pathogen Readiness (MassCPR) and the Musk
Foundation.

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About the Ragon Institute

The Ragon Institute of Mass General, MIT, and Harvard was established in ???? with a gift from the Phillip T. and Susan
M. Ragon Foundation, with a collaborative scientific mission among these institutions to harness the immune
system to combat and cure human diseases. Focusing on global infectious diseases, the Ragon Institute draws
scientists, clinicians and engineers from diverse backgrounds and areas of expertise to study and understand
the immune system with the goal of benefiting patients. For more information, visit www.ragoninstitute.org

About the Massachusetts General Hospital

Massachusetts General Hospital, founded in ????, is the original and largest teaching hospital of Harvard
Medical School. The Mass General Research Institute conducts the largest hospital-based research program in
the nation, with annual research operations of more than $? billion and comprises more than ?,??? researchers
working across more than ?? institutes, centers and departments. In August ????, Mass General was named #?
in the U.S. News & World Report list of
“America’s Best Hospitals.”

About Brigham Health

Brigham Health, a global leader in creating a healthier world, consists of Brigham and Women’s Hospital,
Brigham and Women’s Faulkner Hospital, the Brigham and Women’s Physicians Organization and many related
facilities and programs. With more than ?,??? inpatient beds, approximately ??,??? inpatient stays and ?.?
million outpatient encounters annually, Brigham Health’s ?,??? physicians provide expert care in virtually every
medical and surgical specialty to patients locally, regionally and around the world. An international leader in
basic, clinical and translational research, Brigham Health has nearly ?,??? scientists, including physician –
investigators, renowned biomedical researchers and faculty supported by over $??? million in funding. The
Brigham’s medical preeminence dates back to ????, and now, with ??,??? employees, that rich history is the
foundation for its commitment to research, innovation, and community. Boston-based Brigham and Women’s
Hospital is a teaching affiliate of Harvard Medical School and dedicated to educating and training the next
generation of health care professionals. For more information, resources, and to follow us on social media,
please visit brighamandwomens.org.