Schmidt Lab

Protein Engineering, Therapeutic Development, Viral Evolution

Lab Overview

Our research focuses on the development of adaptive immune responses, protein evolution and the interactions between host and pathogen using a combination of biophysical, biochemical and molecular virology techniques.

We are structural biologists who bring mechanistic and quantitative approaches to address fundamental problems in virology and immunology. We primarily study orthomyxo- and flaviviruses but our interests extend to emerging viruses (e.g. alpha-, arena-, bunya- and filoviruses) and other pathogens. We are strong believers in collaboration and are always open to pursuing new directions and pathogens!

Lab Website

Aaron Schmidt, PhD

Principal Investigator

Affiliation

Core Member, Ragon Institute of Mass General, MIT, and Harvard
Associate Professor in Microbiology, Harvard Medical School
Assistant in Immunology, Massachusetts General Hospital

About

Dr. Schmidt received undergraduate degrees in biology and chemistry from Emmanuel College and a PhD in virology from Harvard University with Stephen C. Harrison. Postdoctoral training was done at Harvard Medical School and Boston Children’s Hospital, also with Stephen C. Harrison.

Related Research Foci

Fundamental Immunology
Global Health
Infectious Disease Pathogenesis

Related Areas of Study

Dengue
Coronaviruses
Influenza

Zika virus
Infectious Disease

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Looking for Collaboration?

Selected Publications

Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza antibody

Schmidt AG, Xu H, Khan AR, O’Donnell T, Khurana S, King LR, Manischewitz J, Golding H, P. Suphaphiphat P,CarfiA, Settembre EC, Dormitzer PR, Kepler TB, Zhang R-J, Moody MA, Haynes BF, Liao HX, Shaw DE and Harrison SC.

PNAS 110, 2013. (1) 264-269

January 1, 2013