Principal Investigator
Core Member
Ragon Institute of Mass General, MIT, and Harvard
Assistant Professor
Department of Biology at MIT
857-268-7031
The Ringel Lab investigates crosstalk between immune cells and their environment at a molecular level, by dissecting metabolic programs engaged under conditions of stress, such as obesity and aging. Using an array of approaches to study metabolic fitness at molecular, cellular, and organism-wide levels, our research aims to reveal both the adaptive molecular changes as well as intrinsic vulnerabilities in immune cells that impact protective responses. Our goal is to understand how disease states remodel the fundamental mechanisms that regulate immune cell function and contribute to pathogenesis.
Dr. Ringel is a Core Member of the Ragon Institute and Assistant Professor in the Biology Department at MIT. She received a bachelor’s degree from Wesleyan University, where she graduated with University Honors and majored in Molecular Biology & Biochemistry and Physics. She performed her graduate studies at the Johns Hopkins University School of Medicine with Dr. Cynthia Wolberger, where she received a PhD in Molecular Biophysics. She moved to Harvard Medical School for postdoctoral training, before joining the Ragon Institute as a core member in 2022.
Ringel, AE, Drijvers, JM, Baker, GJ, Catozzi, A, García-Cañaveras, JC, Gassaway, BM, Miller, BC, Juneja, VR, Nguyen, TH, Joshi, S et al..
2020. Cell 183, 1848-1866.e26.
Drijvers, JM, Gillis, JE, Muijlwijk, T, Nguyen, TH, Gaudiano, EF, Harris, IS, LaFleur, MW, Ringel, AE, Yao, CH, Kurmi, K et al..
2021. Cancer Immunol Res 9, 184-199.
Wong, SJ, Ringel, AE, Yuan, W, Paulo, JA, Yoon, H, Currie, MA, Haigis, MC.
2021. J Biol Chem 296, 100397.
Chakraborty, AA, Laukka, T, Myllykoski, M, Ringel, AE, Booker, MA, Tolstorukov, MY, Meng, YJ, Meier, SR, Jennings, RB, Creech, AL et al..
2019. Science 363, 1217-1222.
Ringel, AE, Tucker, SA, Haigis, MC.
2018. Mol Cell 72, 610-624.
Ringel, AE, Cieniewicz, AM, Taverna, SD, Wolberger, C.
2015. Proc Natl Acad Sci U S A 112, E5461-70
Carmen Morcelle
Postdoctoral Fellow
Our people are our greatest asset. We are committed to creating a supportive and inclusive environment that is welcoming for all.
The Ragon Institute brings together diverse researchers from across Mass General, MIT, and Harvard.
The Ragon’s research creates knowledge from our collaborative, cross-disciplinary approach, breaking down the silos of academia.