Ragon Institute Ringel Lab
Molecular adaptations in immune cells enabling function under stress
Lab Overview
The Ringel Lab investigates crosstalk between immune cells and their environment at a molecular level, by dissecting metabolic programs engaged under conditions of stress, such as obesity and aging. Using an array of approaches to study metabolic fitness at molecular, cellular, and organism-wide levels, our research aims to reveal both the adaptive molecular changes as well as intrinsic vulnerabilities in immune cells that impact protective responses. Our goal is to understand how disease states remodel the fundamental mechanisms that regulate immune cell function and contribute to pathogenesis.
Lab WebsiteAlison Ringel, PhD
Principal Investigator
Affiliation
- Core Member, Ragon Institute of Mass General, MIT, and Harvard
- Assistant Professor, Department of Biology at MIT
About
Dr. Ringel is a Core Member of the Ragon Institute and Assistant Professor in the Biology Department at MIT. She received a bachelor’s degree from Wesleyan University, where she graduated with University Honors and majored in Molecular Biology & Biochemistry and Physics. She performed her graduate studies at the Johns Hopkins University School of Medicine with Dr. Cynthia Wolberger, where she received a PhD in Molecular Biophysics. She moved to Harvard Medical School for postdoctoral training, before joining the Ragon Institute as a core member in 2022.
Related Research Foci
- Cancer Immunology
- Fundamental Immunology
- Infectious Disease Pathogenesis
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Contact UsSelected Publications
Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity.
2020. Cell 183, 1848-1866.e26.
January 1, 2020
Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells.
2021. Cancer Immunol Res 9, 184-199.
January 1, 2021
Development of a colorimetric α-ketoglutarate detection assay for prolyl hydroxylase domain (PHD) proteins.
2021. J Biol Chem 296, 100397.
January 1, 2021
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate.
2019. Science 363, 1217-1222.
January 1, 2019
Chemical and Physiological Features of Mitochondrial Acylation.
2018. Mol Cell 72, 610-624.
January 1, 2018
Nucleosome competition reveals processive acetylation by the SAGA HAT module.
2015. Proc Natl Acad Sci U S A 112, E5461-70
January 1, 2015