The Yu lab studies HIV viruses in diverse groups of participants to investigate possible ways in which the immune system can recognize and combat HIV infection. We study specific types of disease response, like those found in “elite controllers,” people whose immune systems can handle prolonged HIV infection. The lab also looks at how certain innate immune responses, targeting a broad spectrum of pathogens, can be trained to support other immune responses to HIV.
The Yu lab combines basic science immunology with clinical and translational perspectives for improving clinical treatment options for viral infectious disease. Recently, we investigated the proviral reservoirs of “elite controllers,” HIV-1 infected individuals capable of drug-free control of HIV-1 replication despite the presence of a replication-competent viral reservoir. Our research includes the role of dendritic cells and their immunoregulatory functions for generating and fine-tuning adaptive immune responses during HIV-1 infection. Additionally, we analyze immunological networks associated with immune control of HIV-1 and Zika virus using systems biology-based approaches.
Xu Yu is an elected member of the American Society for Clinical Investigation (ASCI), inducted in 2021. She received both the Claflin Distinguished Scholar Award and the Stephen Krane Excellence in Research Award for her work at Massachusetts General Hospital. She has also received the Clinical Scientist Development Award from the Doris Duke Charitable Foundation.
Xu Yu received an MD from China Medical University in Shenyang, China, and completed postdoctoral training in the AIDS Research Center at MGH.
Martin-Gayo E, Cronin J, Hickman T, Ouyang Z, Lindqvist M, Kolb KE, Schulze zur Wiesch J, Cubas R, Porichis F, Shalek A, van Lunzen J, Haddad E, Walker BD, Kaufmann D, Lichterfeld M, Yu XG.
JCI Insight.2017; 2(2):e89574
Sun X, Hua S, Chen HR, Ouyang Z, Einkauf K, Tse S, Ard K, Ciaranello A, Yawetz S, Sax P, Rosenberg ES, Lichterfeld M, Yu XG.
Cell Rep. 2017 Dec 19;21(12):3471-3482
Martin-Gayo E, Cole MB, Kolb KE, Ouyang Z, Cronin J, Kazer SW, Ordovas-Montanes J, Lichterfeld M, Walker BD, Yosef N, Shalek AK, Yu XG
Genome Biology. 2018 Jan 29;19(1):10
Hua S, Vigano S, Tse S, Harrington S, Negron J, Garcia-Broncano P, Resino S, Leal M, Ruiz-Mateos E, Lichterfeld M, Yu XG.
Clin Infect Dis. 2018 Jun 1;66(12):1910-1917
Chowdhury FZ, Ouyang Z, Buzon M, Walker BD, Lichterfeld M, Yu XG.
AIDS, 2018. Nov 28;32(18):2669-2677
Martin-Gayo E, Gao Ce, Chen XR, Ouyang Z, Kim D, Kolb KE, Shalek AK, Walker BD, Lichterfeld M, Yu XG*
Cell Reports. 2020. Jan 28;30(4):984-996.e4.
Sun X, Hua S, Gao C, Blackmer J, Ouyang Z, Ard K, Ciaranello A, Yawetz S, Sax PE, Rosenberg ES, Lichterfeld M, Yu XG*.
Nat Comms. 2020. May 15;11(1):2421. doi: 10.1038/s41467-020-16217-5
Jiang C, Lian L, Gao C, Sun X, Einkauf K, Chevalier JM, Chen S, Hua S, Rhee B, Chang K, Blackmer JE, Osborn M, Peluso MJ, Hoh R, Somsouk M, Milush J, Bertagnolli LN, Sweet S, Varriale J, Burbelo PD, Chun TW, Laird GM, Serrao E, Engelman AN, Carrington M, Siliciano RF, Siliciano J, Deeks SG, Walker BD, Lichterfeld M, Yu XG.
Nature 2020. Aug 26. doi: 10.1038/s41586-020-2651-8
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