Research Highlights
Bryson Lab Study Defines TB Vaccine Targets Directly From Infected Human Cells and Shows How to Deliver Them With mRNA
Nov 6, 2025 Features
A new study led by the Bryson Lab at the Ragon Institute and published in Science Translational Medicine lays out a practical roadmap for making better tuberculosis (TB) vaccines by starting from what infected human immune cells actually show to CD4 T cells. The team used a technique called immunopeptidomics to see which TB proteins infected human immune […]
Kwon and Xavier Labs Map How HIV and Antiretroviral Treatment Alter the Gut Microbiome Across Continents
Oct 30, 2025 Features
A large international study, published in Nature Microbiology and led by the Kwon Lab at the Ragon Institute and the Xavier Lab at the Broad Institute, shows that HIV infection and common antiretroviral drugs change the gut microbiome in distinct, geography-dependent ways. These changes notably may help explain ongoing inflammation and heart-disease risk in people living with HIV. The team analyzed […]
Barczak Lab Leads Study Showing Omicron Subvariants Shed Virus for Similar Periods and Symptoms Alone Do Not Signal Safety
Oct 22, 2025 Features
A new JCI Insight study led by the POSITIVES team and the Barczak Lab at the Ragon Institute followed people with mild COVID-19 to see whether newer Omicron subvariants behave differently over time. Despite ongoing viral evolution, the team found core features—how much viral nucleic acid is found in the nose and how long people […]
Ghebremichael Lab Study Offers a Fairer Way to Judge Medical Tests, Helping Spot Reliable Biomarkers
Sep 29, 2025 Features
A new paper by Ragon Institute biostatisticians in the Ghebremichael Lab introduces and tests a flexible way to grade medical tests like blood-based biomarkers so scientists can more confidently tell which ones truly separate “sick” from “healthy.” That clearer yardstick matters for immunology, where research teams must decide which candidate markers deserve scarce time and funding. Published […]
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Program for Immunophysiology and Disease
Revealing mechanisms of immune control and disease pathogenesis to prepare for and protect against future global health threats.
Program for Immune Engineering
Leveraging discoveries to develop cutting-edge diagnostics and treatments.