Sophia Liu

Sophia Liu, PhD

Principal Investigator

Core Member and Early Independence Fellow

Ragon Institute of Mass General, MIT, and Harvard


Building tools to characterize spatial and temporal immune cell interactions

Research Overview

The Liu lab builds tools to ask new biological questions, in particular for characterizing spatial and temporal dynamics of immune cells in tissues. We aim to study immune cell interactions in tissues, the dynamics across immune development and aging, and T and B cell repertoires in situ

We investigate the dynamic changes that occur in the immune system across different stages of life. We are dedicated to unraveling the complexities of the immune system’s behavior and its critical role in maintaining tissue homeostasis and responding to pathological challenges. By investigating healthy and disease states, we aim to shed light on the processes leading to immune-mediated tissue damage and identify potential therapeutic targets. Recent projects have explored immunological aging of T and B cells, repertoires in cancer and infectious disease contexts, and methods for measuring long-timescale interactions. 


Dr. Sophia Liu received her PhD in Biophysics from Harvard University, supported by the NSF Graduate Fellowship, and is affiliated with the Harvard-MIT Health Sciences and Technology Medical Engineering and Medical Physics Program. She received her BS in Chemical-Biological Engineering from MIT. Through BroadIgnite, she also serves as a Principal Investigator at the Broad Institute of MIT and Harvard.