Dekosky Lab
Efficient Engineering and Discovery of Adaptive Immune Receptors
Lab Overview
Research in the DeKosky lab focuses on developing and applying new techniques to understand the B and T cell responses that make up our adaptive immune memory. These efforts have been applied to better understand immune responses in the context of viral infections, autoimmunity, and cancer. The group’s research efforts have established new high-throughput single-cell platforms to interrogate adaptive immunity and discover precise and targeted protein drugs. We seek to reveal the quantitative principles of adaptive immune protection and advance new immune-based interventions against human diseases.
Lab WebsiteBrandon J. DeKosky, PhD
Principal Investigator
Affiliation
- Core Member, Ragon Institute of Mass General, MIT, and Harvard
- Associate Professor of Chemical Engineering, MIT
About
Dr. DeKosky received a B.S. in chemical engineering from University of Kansas, and his Ph.D. in biochemical engineering at the University of Texas at Austin. His Ph.D. studies were supported by a Hertz Foundation Graduate Fellowship, an NSF Graduate Fellowship, and a Donald. D. Harrington Graduate Fellowship. Dr. DeKosky was also a postdoctoral fellow at the National Institute of Allergy and Infectious Diseases (NIAID) Vaccine Research Center near Washington, D.C., where he worked on new ways to analyze vaccine responses with a focus on major public disease health threats including HIV-1, Zika, and Ebola virus. Brandon launched his independent academic career in 2017 at the University of Kansas before joining The Ragon Institute and MIT Chemical Engineering 2021. Dr. DeKosky now works closely with researchers at The Ragon Institute, Mass General Hospital, and MIT, and he advises trainees from several affiliated academic centers including MIT Chemical Engineering, MIT Bioengineering, Harvard-MIT Health Sciences and Technology, Harvard Immunology, and Harvard Virology training programs.
Recognition & Honors
- Awarded both an NIH Early Independence Award and a K99 Pathway to Independence Award (declined) in 2016 to begin his independent research laboratory
- Received the Department of Defense Career Development Award, the Biomedical Engineering Society Rising Star Award, the AIChE Young Faculty Futures award, the Amgen Young Investigator Award, and the James S. Huston Antibody Science Talent Award
- Serves as a rotating host for the science podcast, “The Chain,” which interviews leading scientists about their careers and to discuss the latest developments in biotech and drug discovery
Related Research Foci
- Cancer Immunology
- Fundamental Immunology
- Global Health
- Mucosal Immunology
- CAR-T / CAR-NK Cells
- FRESH
- Infectious Disease Pathogenesis
- Human Immunogenetics
- AI / ML
- Computational Science
- Immune Monitoring
Related Areas of Study
- Aging
- Epstein-Barr virus
- HIV
- Graft-vs-Host
- Breast cancer
- Cancer
- Colon cancer
- Leukemia
- Lung cancer
- Lymphoma
- Melanoma
- Pancreatic cancer
- Prostate cancer
- Infectious Disease
- Autoimmune
- Allergy
- Coronaviruses
- Ebola
- Hepatitis
- Influenza
- Malaria
- Lyme Disease
- Neuroimmune
- Tuberculosis
- Zika virus
- Human papillomavirus
- Atherosclerosis
Looking for Collaboration?
Contact UsSelected Publications
Antibody directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site
Nature Communications, 14:7593, 2023
Immortalization and Functional Screening of Natively Paired Human T Cell Receptor Repertoires
Protein Engineering, Design, and Selection, 35, (2022)
Mutational Fitness Landscapes of a Broadly Neutralizing Fusion Peptide-Directed Antibody Reveal Multiple Pathways to Improve HIV-1 Neutralization
Proceedings of the National Academy of Sciences of the USA, 118 (10) e2011653118, 2021
Antibody-dependent Enhancement and SARS-CoV-2 Vaccines and Therapies
Nature Microbiology, 5: 1185–1191, 2020.
A molecular trap against COVID-19
Science, 369(6508): 1167-1168, 2020
Functional Interrogation and Mining of Natively-Paired VH:VL Human Antibody Repertoires
Nature Biotechnology, 36: 152–155, 2018.
In-depth determination and analysis of the human paired heavy and light chain antibody repertoire
Nature Medicine, 21(1): 86-91, 2015.
High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire
Nature Biotechnology, 31(2): 166-169, 2013