Ragon Institute

Carrington Lab

Impact of immunogenetic variation on disease outcome

Lab Overview

The Carrington Lab studies the human leukocyte antigen (HLA) class I and class II genetic loci.

The Carrington Lab posits that, while HLA allele disease associations are often attributed to variation at positions that determine specificity for antigenic peptides, there are other mechanisms by which HLA polymorphism influences the immune response. These include HLA class I interactions with innate immune receptors such as KIR and LILR, cell surface expression levels of HLA class I and class II, and allele-specific variation in HLA dependency on tapasin, a key component of the peptide loading complex. Our studies have identified novel HLA associations in a relatively large number of different types of human disorders, including infectious diseases, cancer, autoimmunity, reproductive diseases, and transplantation outcome.

Mary Carrington, PhD

Principal Investigator

Affiliation

  • Steering Committee, Ragon Institute of Mass General, MIT, and Harvard
  • Visiting Professor, Harvard University
  • Senior Principal Investigator, Basic Science Program, Frederick National Laboratory for Cancer Research in the Laboratory of Integrative Cancer Immunology, National Cancer Institute

About

Dr. Carrington obtained her Ph.D. at Iowa State University in the Immunobiology Department. She performed her postdoctoral studies in the departments of Immunology and Microbiology at Duke University and the University of North Carolina. Prior to her current appointments at the Frederick National Laboratory for Cancer Research, the Laboratory of Integrative Cancer Immunology, National Cancer Institute, and the Ragon Institute.

Recognition & Honors

  • Recognized as a Fellow of the American Academy of Microbiology in 2021
  • Gave the AAI President’s Symposium lecture in 2021 and The Terasaki Lecture BSHI/EFI in Glasgow, UK, in 2021
  • Awarded a Visiting Professorship from King’s College, Cambridge University, in Cambridge, the UK in 2018
  • Awarded a Visiting Professorship at Kumamoto University from 2017-2019
  • Awarded a Newton Abraham Professorship at Oxford University, Oxford, UK, from 2015-2016
  • Awarded the 2009 Rose Payne Award in 2009
  • Awarded the Cecil and Ida Green Visiting Professorship, Green College, the University of British Columbia in 2006
  • Awarded the Ceppellini Award, from the European Federation for Immunogenetics in 2005

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Selected Publications

Elevated HLA-A expression impairs HIV control through inhibition of NKG2A expressing cells

Ramsuran, V., Naranbhai, V., Horowitz, A., Qi, Y., Martin, M.P., Yuki, Y., Gao, X., Walker-Sperling, V., Del Prete, G.Q., Schneider, D.K., Lifson, J.D., Fellay, J., Deeks, S.G., Martin, J.N., Goedert, J.J., Wolinsky, S.M., Michael, N.L., Kirk, G.D., Buchbinder, S., Haas, D., Ndung’u, T., Goulder, P., Parham, P., Walker, B.D., Carlson, J.M., and Carrington, M.

Science, 359:86-90, PMID: 29302013, 2018

January 1, 2018
PMID: 29302013

Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1

Martin, M.P., Naranbhai, V., Shea, P.R., Qi, Y., Ramsuran, V., Vince, N., Gao, X., Thomas, R., Brumme, Z.L., Carlson, J.M., Wolinsky, S., Goedert, J.J., Walker, B., Segal, F.P., Deeks, S., Haas, D., Migueles, S., Connors, M., Micheal, N., Fellay, J., Price, D.A., Lafont, B.A., Pymm, P., Saunders, P.M., Widjaja, J., Wong, S.C., Vivian, J.P., Rossjohn, J., Brooks, A.G., and Carrington, M.

J. Clin. Invest., PMID: 29461980, 128:1903-1912, 2018

January 1, 2018
PMID: 29461980

Topological perspective on HIV escape

McMichael, A.J. and Carrington, M.

Science, PMID: 31048479, 364:438-439, 2019

January 1, 2019
PMID: 31048479

CCR5AS IncRNA variation differentially regulates CCR5, influencing viral disease outcome

Kulkarni, S., Lied, A., Kulkarni, V., Rucevic, M., Ewy, R., Singh, S., McLaren, P.J., Viard, M., Martin, M.P., Naranbhai, V., Zou, C., Lin, Z., Gatanaga, H., Oka, S., Takiguchi, M., Thio, C.L., Margolick, J., Kirk, G.D., Goedert, J.J., Hoots, W.K., Deeks, S.G., Haas, D.W., Michael, N., Walker, B., Le Gall, S., Chowdhury, F., Yu, X.G., and Carrington, M.

Nat. Immunol., PMID: 31209403, 20:824-834, 2019

January 1, 2019
PMID: 31209403

A subset of HLA-DP molecules serve as ligands for the natural cytotoxicity receptor NKp44

Niehrs, A., Garcia-Beltran, W.F., Norman, P.J., Watson, G.M., Holzemer, A., Chapel, A., Richert, L., Pommerening-Roser, A., Korner, C., Ozawa, M., Martrus, G., Rossjohn, J., Lee, J-H., Berry, R., Carrington, M., and Altfeld, M.

Nat. Immunol., PMID: 31358998, 20:1129-1137, 2019

January 1, 2019
PMID: 31358998

HLA-B leader and survivorship after HLA-mismatched unrelated donor transplantation

Petersdorf, E.W., Stevenson, P., Bengtsson, M., De Santis, D., Dubois, V., Gooley, T., Horowitz, M., Hsu, K., Madrigal, J.A., Malkki, M., McKallor, C., Morishima, Y., Oudshoorn, M., Spellman, S.R., Villard, J., Carrington, M.

Blood, PMID: 32483623, 136:362-369, 2020

January 1, 2020
PMID: 32483623

HLA tapasin independence: broader peptide repertoire and HIV control

Bashirova, A.A., Viard, M., Naranbhai, V., Grifoni, A., Garcia-Beltran, W., Akdag, M., Yuki, Y., Gao, X., O’hUigin, C., Raghavan, M., Wolinsky, S., Bream, J.H., Duggal, P., Martinson, J., Michael, N.L., Kirk, G.D., Buchbinder, S.P., Haas, D., Goedert, J.J., Deeks, S.G., Fellay, J., Walker, B., Goulder, P, Cresswell, P., Elliott, T., Sette, A., Carlson, J. and Carrington, M.

PNAS, PMID: 33097667, 117:28232-28238, 2020

January 1, 2020
PMID: 33097667
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Lab Team

Zhansong Lin

Research Fellow

Pedro Ojeda

Research Technician II

Victoria Walker-Sperling

Research Fellow

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240-760-6055

[email protected]

Bethesda, MD

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