Ragon Institute Akeem Akilimali
Alumni - Postdoc University of Pennsylvania
Bryson Lab
Immune control of mycobacteria
Lab Overview
The Bryson lab is working to determine how cells of the immune system control and eliminate one of the world’s most deadly pathogens, Mycobacterium tuberculosis (Mtb).
http://brysonlab.mit.edu/How Mycobacterium tuberculosis is controlled by humans remains a poorly understood process. To address this knowledge gap, our research group combines approaches in microbiology, immunology, and bioengineering to understand and manipulate the complexity of phagocyte state and function in the lung. Paired with these cellular questions, our group develops novel tools to query and perturb the phagosome which we hypothesize contributes to effective Mtb control.
Bryan Bryson, PhD
Principal Investigator
Affiliation
- Core Member, Ragon Institute of Mass General, MIT, and Harvard
- Associate Professor, MIT Department of Biological Engineering
- Associate Member, Broad Institute
About
Dr. Bryson received a BS in Mechanical Engineering and PhD in Biological Engineering from MIT. He pursued postdoctoral training at the Harvard TH Chan School of Public Health with Sarah Fortune, where he became fascinated by the complexity of interactions between Mtb and the host. He joined the MIT faculty in 2018 and was promoted to Associate Professor Without Tenure in 2022.
Related Research Foci
- Artificial Intelligence and Machine Learning
- Computational Science
- Fundamental Immunology
- Infectious Disease Pathogenesis
- Global Health
Related Areas of Study
- Infectious Disease
- Tuberculosis
Looking for Collaboration?
Contact UsSelected Publications
GM-CSF differentiation of human monocytes stabilizes macrophage state via oxidative signaling
bioRxiv 2020.09.29.318352 (2020) doi:10.1101/2020.09.29.318352
September 29, 2020
Computational Methods for Single-Cell RNA Sequencing
Annu. Rev. Biomed. Data Sci. 3, 339–364 (2020)
January 1, 2020
Consensus transcriptional states describe human mononuclear phagocyte diversity in the lung across health and disease
bioRxiv 2020.08.06.240424 (2020) doi:10.1101/2020.08.06.240424
August 6, 2020
Single-cell profiling of tuberculosis lung granulomas reveals functional lymphocyte signatures of bacterial control
bioRxiv 2020.10.24.352492 (2020) doi:10.1101/2020.10.24.352492
October 24, 2020
Leveraging Uncertainty in Machine Learning Accelerates Biological Discovery and Design
Cell Syst. (2020) doi:10.1016/j.cels.2020.09.007
January 1, 2020
Single Cell and Spatial Transcriptomics Defines the Cellular Architecture of the Antimicrobial Response Network in Human Leprosy Granulomas
bioRxiv 2020.12.01.406819 (2020) doi:10.1101/2020.12.01.406819
December 1, 2020
mSphere of Influence: the Complexity of Interferon Gamma-Mediated Pathogen Control
mSphere 6, (2021)
January 1, 2021
Learning the language of viral evolution and escape
Science 371, 284–288 (2021)
January 1, 2021
Lab Team
Ben Allsup
Graduate Student
Diana Gong
Alumni -
Cal Gunnarson
Postdoc
Lerato Hlaka
Postdoc
Jacob Hochfelder
Graduate Student
Owen Leddy
Alumni- Postdoc UCSD
Bianca Lepe
Alumni - Data Scientist for the City of Boston
Josh Peters
Alumni - CEO and Co-founder at Arpelos
Sydney Solomon
Alumni - Principal Scientist at Novartis
Christine Zheng
Graduate Student
Bryson Lab
Lab Life
