Ragon Institute

Bryson Lab

Immune control of mycobacteria

Lab Overview

The Bryson lab is working to determine how cells of the immune system control and eliminate one of the world’s most deadly pathogens, Mycobacterium tuberculosis (Mtb).
http://brysonlab.mit.edu/How Mycobacterium tuberculosis is controlled by humans remains a poorly understood process. To address this knowledge gap, our research group combines approaches in microbiology, immunology, and bioengineering to understand and manipulate the complexity of phagocyte state and function in the lung. Paired with these cellular questions, our group develops novel tools to query and perturb the phagosome which we hypothesize contributes to effective Mtb control.

Lab Website

Bryan Bryson, PhD

Principal Investigator

Affiliation

  • Core Member, Ragon Institute of Mass General, MIT, and Harvard
  • Associate Professor, MIT Department of Biological Engineering
  • Associate Member, Broad Institute

About

Dr. Bryson received a BS in Mechanical Engineering and PhD in Biological Engineering from MIT. He pursued postdoctoral training at the Harvard TH Chan School of Public Health with Sarah Fortune, where he became fascinated by the complexity of interactions between Mtb and the host. He joined the MIT faculty in 2018 and was promoted to Associate Professor Without Tenure in 2022.

Related Research Foci

  • Artificial Intelligence and Machine Learning
  • Computational Science
  • Fundamental Immunology
  • Infectious Disease Pathogenesis
  • Global Health
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Related Areas of Study

  • Infectious Disease
  • Tuberculosis

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Selected Publications

GM-CSF differentiation of human monocytes stabilizes macrophage state via oxidative signaling

Itoh, C. Y. et al.

bioRxiv 2020.09.29.318352 (2020) doi:10.1101/2020.09.29.318352

September 29, 2020

Computational Methods for Single-Cell RNA Sequencing

Annu. Rev. Biomed. Data Sci. 3, 339–364 (2020)

January 1, 2020

Consensus transcriptional states describe human mononuclear phagocyte diversity in the lung across health and disease

Peters, J. M., Blainey, P. C. & Bryson, B. D.

bioRxiv 2020.08.06.240424 (2020) doi:10.1101/2020.08.06.240424

August 6, 2020

Single-cell profiling of tuberculosis lung granulomas reveals functional lymphocyte signatures of bacterial control

Gideon, H. P. et al.

bioRxiv 2020.10.24.352492 (2020) doi:10.1101/2020.10.24.352492

October 24, 2020

Leveraging Uncertainty in Machine Learning Accelerates Biological Discovery and Design

Hie, B., Bryson, B. D. & Berger, B.

Cell Syst. (2020) doi:10.1016/j.cels.2020.09.007

January 1, 2020

Single Cell and Spatial Transcriptomics Defines the Cellular Architecture of the Antimicrobial Response Network in Human Leprosy Granulomas

Ma, F. et al.

bioRxiv 2020.12.01.406819 (2020) doi:10.1101/2020.12.01.406819

December 1, 2020

mSphere of Influence: the Complexity of Interferon Gamma-Mediated Pathogen Control

Bryson, B. D.

mSphere 6, (2021)

January 1, 2021

Learning the language of viral evolution and escape

Hie, B., Zhong, E. D., Berger, B. & Bryson, B.

Science 371, 284–288 (2021)

January 1, 2021

Lab Team

Ben Allsup

Graduate Student

Yufei Chen

UROP

Arianna Doss

UROP

Cal Gunnarson, PhD

Postdoc

Lerato Hlaka, PhD

Postdoc

Jacob Hochfelder

Graduate Student

Anna Kim

UROP

Sheikh Mahmud

UROP

Rachel McGinn

Graduate Student

Ryan Milligan

Technician

Heyuan “Michael” Ni

Graduate Student

Jonathan Padilla Gomez, PhD

Postdoc

Mateo Stagg

UROP

Julia Van der Marel

UROP

Christine Zheng

Graduate Student

Diane Ballestas

Lab Administrator

Lab Alumni

  • Chris Itoh MD, PGY4 Neurology Resident at Mayo Clinic Neurology
  • Brian Hie PhD, Assistant Professor at Stanford University
  • Joshua Peters PhD, CEO and Co-founder at Arpelos
  • Sydney Solomon PhD, Principal Scientist at Novartis
  • Akeem Ngomu Akilimali PhD, Senior Research Scientist at University of Pennsylvania Center for Cellular Immunotherapies
  • Iris Abrahantes Morales, Medical student at Emory University School of Medicine
  • Bianca Lepe PhD, Data Scientist for the City of Boston
  • Diana Gong PhD, Instructor at Stanford University
  • Owen Leddy PhD, Postdoctoral researcher at University of California San Diego

Lab Life

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