Zaza Ndhlovu

Zaza Ndhlovu, PhD

Principal Investigator


Assistant Professor

Ragon Institute of MGH, MIT and Harvard

Associate Professor

Africa Health Research Institute, University of KwaZulu Natal

Assistant in Immunology

Massachusetts General Hospital

Contact


617-301-2032

Visit Lab Website

Lymphoid tissues, Acute HIV-1 infection, HIV cure

Research Overview

The ultimate solution for HIV infected people on lifelong therapy is to find a cure. My research uses lymph node and large blood donations from a cohort of individuals who initiate therapy immediately upon diagnosis of acute HIV infection to identify where the HIV reservoir resides within tissues and define immune components that mediate HIV reservoir suppression.

Improved understanding of the HIV reservoir in tissues is critical to curative efforts. My lab uses serial excisional lymph node and leukapheresis samples obtained from individuals initiating ARTduring hyperacute HIV infection to define the interplay between early virological and cellular immune responses and the impact of these interactions on viral control, reservoir establishment, cellular distribution, and decay dynamics. By determining the impact that very early ART has on these parameters, we will be able to provide guidance for future vaccine and immunotherapeutic strategies not just for early treated individuals but for persons requiring long-term ART.

Recognition and Media

Howard Hughes International Scholar Award Gates Foundation Grand challenges Award

About

Dr. Zaza Ndhlovu is a viral Immunologist. He received his PhD in Molecular Microbiology and Immunology at Johns Hopkins University, Baltimore Maryland, and did his post-doctoral training at Harvard University. He is an Assistant Professor at the Ragon Institute of MGH, MIT and Harvard, Faculty member at Africa health Research Institute, and adjunct Associate Professor at the University of KwaZulu Natal. He is also a visiting scientist at the center for Infectious Diseases in Zambia and an HHMI international research scholar.

Lab Team

Caroline Chasara

Graduate Student

Trevor Khaba

Research Technician I

Bongiwe Mahlobo

Graduate Student

Anele Mbatha

Research Technician I

Namani Ngema

Graduate Student

Tiza Ngu’ni

Postdoctoral Fellow

Thandeka Nkosi

Lab Manager

Mzabalazo Nsimbi

Research Technician I

Andrea Papadopoulos

Postdoctoral Fellow

Werner Smidt

Postdoctoral Fellow