Mathias D. Lichterfeld

Mathias D. Lichterfeld, MD, PhD

Principal Investigator


Ragon Institute of Mass General, MIT, and Harvard

Professor of Medicine

Harvard Medical School

Staff Physician

Infectious Disease Division, Brigham and Women’s Hospital and Massachusetts General Hospital


(617) 724-6454

400TS 1024

Clinical Trials, Single Cell assays, HIV Cure

Research Overview

The Lichterfeld lab studies HIV-infected cells that persist in infected individuals despite currently available antiretroviral therapy. Information gleaned from these studies will help us better understand how the immune system can eradicate cells infected with HIV and ultimately contribute to finding a cure for HIV infection.

The Lichterfeld lab focuses on multidimensional profiling of HIV-1 reservoir cells – HIV-1-infected cells that persist despite currently available antiretroviral therapy and represent the main barrier to a cure for HIV-1 infection. In this context, we use novel single-cell assays in combination with bioinformatics approaches to evaluate the susceptibilities and vulnerabilities of these cells. It analyzes their responsiveness to clinical interventions in human clinical trials. A particular area of programmatic emphasis is the analysis of viral reservoirs and antiviral immune responses in infected neonates, children, and teenagers, in whom novel approaches for HIV cure and eradication may be most consequential. 

Recognition and Media

Dr. Lichterfeld was named a fellow of the Infectious Disease Society of America (FIDSA) and elected a member of the American Society for Clinical Investigation (ASCI) in 2015. He is also a permanent member of the HIV Immunopathogenesis and Vaccine Development (HIVD) study section at the NIH Center for Scientific Review.


Dr. Mathias Lichterfeld is an infectious disease physician who works as a basic science and translational investigator, a clinical care provider, and a mentor and educator for residents and clinical/research fellows. Dr. Lichterfeld is a Professor of Medicine at Harvard Medical School and Co-Director of the Harvard University Center for AIDS Research (CFAR) Program on HIV Eradication. He is also a senior staff physician in the Infectious Disease Division of Brigham and Women’s Hospital (BWH) and MGH; a Member of the Ragon Institute of Mass General, MIT, and Harvard; and an Associate Member of the Broad Institute of MIT and Harvard.

Selected Publications

Selection of epigenetically privileged HIV-1 proviruses during treatment with panobinostat and interferon-α2a

Armani-Tourret M, Gao C, Hartana CA, Sun W, Carrere L, Vela L, Hochroth A, Bellefroid M, Sbrolla A, Shea K, Flynn T, Roseto I, Rassadkina Y, Lee C, Giguel F, Malhotra R, Bushman FD, Gandhi RT, Yu XG, Kuritzkes DR, Lichterfeld M.

Cell 2024 187:1238-1254 PubMed

Anti-apoptotic Protein BIRC5 Maintains Survival of HIV-1-Infected CD4+ T Cells

Kuo HH, Ahmad R, Lee GQ, Gao C, Chen HR, Ouyang Z, Szucs MJ, Kim D, Tsibris A, Chun TW, Battivelli E, Verdin E, Rosenberg ES, Carr SA, Yu XG, Lichterfeld M.

Immunity. 2018; 48:1183-1194 PubMed Read on Journal Site

Broadly neutralizing antibody treatment maintained HIV suppression in children with favorable reservoir characteristics in Botswana

Shapiro RL, Ajibola G, Maswabi K, Hughes M, Nelson BS, Niesar A, Pretorius Holme M, Powis KM, Sakoi M, Batlang O, Moyo S, Mohammed T, Maphorisa C, Bennett K, Hu Z, Giguel F, Reeves JD, Reeves MA, Gao C, Yu X, Ackerman ME, McDermott A, Cooper M, Caskey M, Gama L, Jean-Philippe P, Yin DE, Capparelli EV, Lockman S, Makhema J, Kuritzkes DR, Lichterfeld M.

Sci Transl Med. 2023; 15(703), eadh0004 PubMed Read on Journal Site

Phenotypic signatures of immune selection in HIV-1 reservoir cells

Sun W, Gao C, Hartana CA, Osborn MR, Einkauf KB, Lian X, Bone B, Bonheur N, Chun TW, Rosenberg ES, Walker BD, Yu XG, Lichterfeld M.

Nature. 2023; 614:309-317 Read on Journal Site

Progressive transformation of the HIV-1 reservoir cell profile over two decades of antiviral therapy

Lian X, Seiger KW, Parsons EM, Gao C, Sun W, Gladkov GT, Roseto IC, Einkauf KB, Osborn MR, Chevalier JM, Jiang C, Blackmer J, Carrington M, Rosenberg ES, Lederman MM, McMahon DK, Bosch RJ, Jacobson JM, Gandhi RT, Peluso MJ, Chun TW, Deeks SG, Yu XG, Lichterfeld M.

Cell Host Microbe 2023 31:1-14 Download PDF Read on Journal Site

Immune correlates of HIV-1 reservoir cell decline in early-treated infants

Hartana CA, Garcia-Broncano P, Rassadkina Y, Lian X, Jiang C, Einkauf KB, Maswabi K, Ajibola G, Moyo S, Mohammed T, Maphorisa C, Makhema J, Yuki Y, Martin M, Bennett K, JEn-Philippe P, Viard M, Hughes MD, Powis KM, Carrington M, Lockman S, Gao C, Yu XG, Kuritzkes DR, Shapiro R, Lichterfeld M.

Cell Reports 2022 40(3):111126 Download PDF PubMed Read on Journal Site

Parallel analysis of transcription, integration, and sequence of single HIV-1 proviruses

Einkauf KB, Osborn MR, Gao C, Sun W, Sun X, Lian X, Parsons EM, Gladkov GT, Seiger KW, Black JE, Jiang C, Yukl SA, Rosenberg ES, Yu XG, Lichterfeld M.

Cell 2022 185(2):266-282 Download PDF PubMed Read on Journal Site

Blood and Lymph Node Dissemination of Clonal Genome-Intact Human Immunodeficiency Virus 1 DNA Sequences During Suppressive Antiretroviral Therapy

Kuo HH, Banga R, Lee GQ, Gao C, Cavassini M, Corpataux JM, Blackmer JE, Zur Wiesch S, Yu XG, Pantaleo G, Perreau M, Lichterfeld M.

J Infect Dis. 2020 222(4):655-660 Download PDF PubMed Read on Journal Site

Lab Team

Maxime Bellefroid

Research Fellow

Leah Carrere

Research Technician I

Ce Gao

Instructor In Medicine

Seohyun Hong

Research Technician I

Sruthi Kalavacherla

Undergraduate Student

Catherine Koofhethile

Research Fellow

Aischa Niesar

Graduate Student

Wei Wei Sun

Research Fellow

Marie Armani Tourret

Research Fellow

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