The Lichterfeld lab studies HIV-infected cells that persist in infected individuals despite currently available antiretroviral therapy. Information gleaned from these studies will help us better understand how the immune system can eradicate cells infected with HIV and ultimately contribute to finding a cure for HIV infection.
The Lichterfeld lab focuses on multidimensional profiling of HIV-1 reservoir cells – HIV-1-infected cells that persist despite currently available antiretroviral therapy and represent the main barrier to a cure for HIV-1 infection. In this context, we use novel single-cell assays in combination with bioinformatics approaches to evaluate the susceptibilities and vulnerabilities of these cells. It analyzes their responsiveness to clinical interventions in human clinical trials. A particular area of programmatic emphasis is the analysis of viral reservoirs and antiviral immune responses in infected neonates, children, and teenagers, in whom novel approaches for HIV cure and eradication may be most consequential.
Dr. Lichterfeld was named a fellow of the Infectious Disease Society of America (FIDSA) and elected a member of the American Society for Clinical Investigation (ASCI) in 2015. He is also a permanent member of the HIV Immunopathogenesis and Vaccine Development (HIVD) study section at the NIH Center for Scientific Review.
Dr. Mathias Lichterfeld is an infectious disease physician who works as a basic science and translational investigator, a clinical care provider, and a mentor and educator for residents and clinical/research fellows. Dr. Lichterfeld is a Professor of Medicine at Harvard Medical School and Co-Director of the Harvard University Center for AIDS Research (CFAR) Program on HIV Eradication. He is also a senior staff physician in the Infectious Disease Division of Brigham and Women’s Hospital (BWH) and MGH; an Associate Member of the Ragon Institute of Mass General, MIT, and Harvard; and an Associate Member of the Broad Institute of MIT and Harvard.
Shapiro RL, Ajibola G, Maswabi K, Hughes M, Nelson BS, Niesar A, Pretorius Holme M, Powis KM, Sakoi M, Batlang O, Moyo S, Mohammed T, Maphorisa C, Bennett K, Hu Z, Giguel F, Reeves JD, Reeves MA, Gao C, Yu X, Ackerman ME, McDermott A, Cooper M, Caskey M, Gama L, Jean-Philippe P, Yin DE, Capparelli EV, Lockman S, Makhema J, Kuritzkes DR, Lichterfeld M.
Sun W, Gao C, Hartana CA, Osborn MR, Einkauf KB, Lian X, Bone B, Bonheur N, Chun TW, Rosenberg ES, Walker BD, Yu XG, Lichterfeld M.
Nature. 2023; 614:309-317 Read on Journal Site
Lian X, Seiger KW, Parsons EM, Gao C, Sun W, Gladkov GT, Roseto IC, Einkauf KB, Osborn MR, Chevalier JM, Jiang C, Blackmer J, Carrington M, Rosenberg ES, Lederman MM, McMahon DK, Bosch RJ, Jacobson JM, Gandhi RT, Peluso MJ, Chun TW, Deeks SG, Yu XG, Lichterfeld M.
Hartana CA, Garcia-Broncano P, Rassadkina Y, Lian X, Jiang C, Einkauf KB, Maswabi K, Ajibola G, Moyo S, Mohammed T, Maphorisa C, Makhema J, Yuki Y, Martin M, Bennett K, JEn-Philippe P, Viard M, Hughes MD, Powis KM, Carrington M, Lockman S, Gao C, Yu XG, Kuritzkes DR, Shapiro R, Lichterfeld M.
Einkauf KB, Osborn MR, Gao C, Sun W, Sun X, Lian X, Parsons EM, Gladkov GT, Seiger KW, Black JE, Jiang C, Yukl SA, Rosenberg ES, Yu XG, Lichterfeld M.
Kuo HH, Banga R, Lee GQ, Gao C, Cavassini M, Corpataux JM, Blackmer JE, Zur Wiesch S, Yu XG, Pantaleo G, Perreau M, Lichterfeld M.
Garcia-Broncano P, Maddali S, Einkauf KB, Jiang C, Gao C, Chevalier J, Chowdhury FZ, Maswabi K, Ajibola G, Moyo S, Mohammed T, Ncube T, Makhema J, Jean-Philippe P, Yu XG, Powis KM, Lockman S, Kuritzkes DR, Shapiro R, Lichterfeld M.
Research Technician I
Instructor In Medicine
Research Technician I
Wei Wei Sun
Marie Armani Tourret
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