Mathias D. Lichterfeld

Mathias D. Lichterfeld, MD, PhD

Principal Investigator


Member

Ragon Institute of MGH, MIT and Harvard

Associate Professor of Medicine

Harvard Medical School

Staff Physician

Infectious Disease Division, Brigham and Women’s Hospital and Massachusetts General Hospital

Contact


(617) 724-6454

400TS 1024

Clinical Trials, Single Cell assays, HIV Cure

Research Overview

The Lichterfeld lab studies HIV-infected cells that persist in infected individuals despite currently available antiretroviral therapy. Information gleaned from these studies will help us better understand how the immune system can eradicate cells infected with HIV and ultimately contribute to finding a cure for HIV infection.

The Lichterfeld lab focuses on multidimensional profiling of HIV-1 reservoir cells – HIV-1-infected cells that persist despite currently available antiretroviral therapy and represent the main barrier to a cure for HIV-1 infection. In this context, we use novel single-cell assays in combination with bioinformatics approaches to evaluate the susceptibilities and vulnerabilities of these cells. It analyzes their responsiveness to clinical interventions in human clinical trials. A particular area of programmatic emphasis is the analysis of viral reservoirs and antiviral immune responses in infected neonates, children, and teenagers, in whom novel approaches for HIV cure and eradication may be most consequential. 

Recognition and Media

Dr. Lichterfeld was named a fellow of the Infectious Disease Society of America (FIDSA) and elected a member of the American Society for Clinical Investigation (ASCI) in 2015. He is also a permanent member of the HIV Immunopathogenesis and Vaccine Development (HIVD) study section at the NIH Center for Scientific Review.

About

Dr. Mathias Lichterfeld is an infectious disease physician who works as a basic science and translational investigator, a clinical care provider, and a mentor and educator for residents and clinical/research fellows. Dr. Lichterfeld is a Professor of Medicine at Harvard Medical School and Co-Director of the Harvard University Center for AIDS Research (CFAR) Program on HIV Eradication. He is also a senior staff physician in the Infectious Disease Division of Brigham and Women’s Hospital (BWH) and MGH; an Associate Member of the Ragon Institute of MGH, MIT and Harvard; and an Associate Member of the Broad Institute of MIT and Harvard.

Selected Publications

Phenotypic signatures of immune selection in HIV-1 reservoir cells

Sun W, Gao C, Hartana CA, Osborn MR, Einkauf KB, Lian X, Bone B, Bonheur N, Chun TW, Rosenberg ES, Walker BD, Yu XG, Lichterfeld M.

Nature 2023 Read on Journal Site

Progressive transformation of the HIV-1 reservoir cell profile over two decades of antiviral therapy

Lian X, Seiger KW, Parsons EM, Gao C, Sun W, Gladkov GT, Roseto IC, Einkauf KB, Osborn MR, Chevalier JM, Jiang C, Blackmer J, Carrington M, Rosenberg ES, Lederman MM, McMahon DK, Bosch RJ, Jacobson JM, Gandhi RT, Peluso MJ, Chun TW, Deeks SG, Yu XG, Lichterfeld M.

Cell Host Microbe 2023 31:1-14 Download PDF Read on Journal Site

Immune correlates of HIV-1 reservoir cell decline in early-treated infants

Hartana CA, Garcia-Broncano P, Rassadkina Y, Lian X, Jiang C, Einkauf KB, Maswabi K, Ajibola G, Moyo S, Mohammed T, Maphorisa C, Makhema J, Yuki Y, Martin M, Bennett K, JEn-Philippe P, Viard M, Hughes MD, Powis KM, Carrington M, Lockman S, Gao C, Yu XG, Kuritzkes DR, Shapiro R, Lichterfeld M.

Cell Reports 2022 40(3):111126 Download PDF PubMed Read on Journal Site

Parallel analysis of transcription, integration, and sequence of single HIV-1 proviruses

Einkauf KB, Osborn MR, Gao C, Sun W, Sun X, Lian X, Parsons EM, Gladkov GT, Seiger KW, Black JE, Jiang C, Yukl SA, Rosenberg ES, Yu XG, Lichterfeld M.

Cell 2022 185(2):266-282 Download PDF PubMed Read on Journal Site

Blood and Lymph Node Dissemination of Clonal Genome-Intact Human Immunodeficiency Virus 1 DNA Sequences During Suppressive Antiretroviral Therapy

Kuo HH, Banga R, Lee GQ, Gao C, Cavassini M, Corpataux JM, Blackmer JE, Zur Wiesch S, Yu XG, Pantaleo G, Perreau M, Lichterfeld M.

J Infect Dis. 2020 222(4):655-660 Download PDF PubMed Read on Journal Site

Early antiretroviral therapy in neonates with HIV-1 infection restricts viral reservoir size and induces a distinct innate immune profile

Garcia-Broncano P, Maddali S, Einkauf KB, Jiang C, Gao C, Chevalier J, Chowdhury FZ, Maswabi K, Ajibola G, Moyo S, Mohammed T, Ncube T, Makhema J, Jean-Philippe P, Yu XG, Powis KM, Lockman S, Kuritzkes DR, Shapiro R, Lichterfeld M.

Sci Transl Med. 2019 11(520):eaax7350 Download PDF PubMed Read on Journal Site

Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy

Einkauf K, Lee GQ, Gao C, Sharaf R, Sun X, Hua s, Chen S, Jiang C, Lian X, Chowdhury FZ, Rosenberg ES, Chun TW, Li JZ, Yu XG, Lichterfeld M.

J Clin Invest 2019, 129:988-998 Download PDF PubMed Read on Journal Site

HIV-1 DNA sequence diversity and evolution during acute subtype C infection

Lee GQ, Reddy K, Einkauf KB, Gounder K, Chevalier JM, Dong KL, Walker BD, Yu XG, Ndung'u T, Lichterfeld M.

Nat Commun. 2019 Jun 21;10(1):2737. doi: 10.1038/s41467-019-10659-2 Download PDF PubMed Read on Journal Site

Lab Team

Maxime Bellefroid

Research Fellow

Leah Carrere

Research Technician I

Ce Gao

Research Scientist

Gregory Gladkov

Senior Research Technologist

Seohyun Hong

Research Technician I

Aischa Niesar

Graduate Student

Isabelle Roseto

Research Technician II

Wei Wei Sun

Research Fellow

Toong Seng Tan

Research Fellow

Liliana Vela

Research Technician I

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