Favicon
Favicon

Of Mice and Men

Date: December 5, 2012 By:

Will those hard-working humanized mice help get us to an AIDS vaccine? Scientists are sounding more optimistic.

 

“Allen led a recent study that caused a small stir in AIDS vaccine research circles. He and his colleagues found that BLT mice infected with HIV mounted cellular immune responses that closely mirrored those observed in HIV-infected humans, and moreover that HIV also escaped from those responses in a manner very similar to natural infection. Finally, Allen and his team found that BLT mice carrying a human immune-related gene associated with enhanced control of viral replication suppressed the virus in a way that was virtually identical to how humans who express that same gene control the virus. Allen said his lab is now looking at the potential to induce human HIV-specific immune responses in the humanized mice through vaccination.”

 

Dr. Todd Allen featured in VAX magazine article (Dec 2012).

More News

Ragon at Pride for the People 2024

Celebrating Pride Month, we are delighted to share moments from the Boston Pride for the People Parade that took place on June 8. Members of the Ragon community joined the vibrant event, celebrating the history and meaning behind this month.

Press Releases

Research shows early life immunity increases HIV cure/remission in male infants

New research published today by scientists at the Ragon Institute of Mass General Brigham, MIT and Harvard, the University of Oxford, the University of KwaZulu-Natal and the African Health Research Institute in South Africa, shows that male infants are more likely to achieve HIV cure/remission than females.

Press Releases

New target in sight for HIV vaccine development

Decades into the HIV epidemic, there is as yet no effective vaccine to prevent new cases. In a recent Nature Immunology article (Ray et al.), the Batista lab of the Ragon Institute has preclinically validated a new HIV immunogen design approach from the Scripps Institute’s Schief lab targeting an unexplored site on the HIV-1 Envelope protein (Env).