The Evavold lab studies fundamental cellular decision making towards different cell fates using cell death programs as a model system. We have a particular interest in the intersection of microbiology and metabolism with impact on host cell survival or death.
Regulated cell death can serve different functions within the innate immune system. For example, immunologically silent cell death can remove unnecessary, damaged, or pre-malignant cells during development and homeostasis. Alternatively, during the early containment of a pathogen, inflammatory cell death can alert the immune system to a foreign invader. However, inflammatory cell death can become pathogenic during systemic infection or contribute to sterile autoimmunity and chronic inflammation. Conversely, acquired resistance to cell death programs can promote cancer progression or resistance to chemotherapies. Dysfunction of cell death regulation may underlie much of the pathology related to human diseases. Thus, we aim to uncover novel regulation in these processes using precision screening that combines genomic or chemical perturbations with synthetic biology models of discrete signaling nodes.
Dr. Charlie Evavold received his PhD in Immunology from Harvard University. He received his BS in Physics and Astronomy with a double major in Chemistry from Emory University. Charlie is one of the inaugural Ragon Early Independence Fellows on the basic science track.
Pascal Devant, Elvira Boršić, Elsy M Ngwa, Haopeng Xiao, Edward T Chouchani, Jay R Thiagarajah, Iva Hafner-Bratkovič, Charles L Evavold, Jonathan C Kagan
Cell Reports 2023, 42(1):112008 Download PDF PubMed Read on Journal Site
Shivangi Rastogi, Charles L Evavold, Volker Briken
Cell Host & Microbe 2022, Volume 30, Issue 12, p1650-1652 Download PDF PubMed Read on Journal Site
Jazlyn P Borges, Ragnhild SR Sætra, Allen Volchuk, Marit Bugge, Pascal Devant, Bjørnar Sporsheim, Bridget R Kilburn, Charles L Evavold, Jonathan C Kagan, Neil M Goldenberg, Trude Helen Flo, Benjamin Ethan Steinberg
Elife 2022, 11:e78609 Download PDF PubMed Read on Journal Site
Isabella R Fraschilla, Charles L Evavold
Frontiers in Immunology 2022, 13:923024. Download PDF PubMed Read on Journal Site
Charles L Evavold, Jonathan C. Kagan
Frontiers in Cell and Developmental Biology 2022, 10:910983 Download PDF PubMed Read on Journal Site
Charles L Evavold, Iva Hafner-Bratkovič, Pascal Devant, Jasmin M D’Andrea, Elsy M Ngwa, Elvira Boršic, John G Doench, Martin W LaFleur, Arlene H Sharpe, Jay R Thiagarajah, Jonathan C Kagan
Cell 2021, Volume 184, Issue 17, Pages 4495-4511.e19 Download PDF PubMed Read on Journal Site
Venkat Giri Magupalli, Roberto Negro, Yuzi Tian, Arthur V Hauenstein, Giuseppe Di Caprio, Wesley Skillern, Qiufang Deng, Pontus Orning, Hasan B Alam, Zoltan Maliga, Humayun Sharif, Jun Jacob Hu, Charles L Evavold, Jonathan C Kagan, Florian I Schmidt, Katherine A Fitzgerald, Tom Kirchhausen, Yongqing Li, Hao Wu
Science 2020, Vol 369, Issue 6510 Download PDF PubMed Read on Journal Site
Charles L Evavold, Jonathan C Kagan
Immunity 2019, Volume 51, Issue 4, p609–624 Download PDF PubMed Read on Journal Site