Ragon Institute of MGH, MIT and Harvard
Senior Principal Investigator
Basic Science Program, Frederick National Laboratory for Cancer Research in the Laboratory of Integrative Cancer Immunology, National Cancer Institute
The Carrington Lab studies the human leukocyte antigen (HLA) class I and class II genetic loci.
The Carrington Lab posits that, while HLA allele disease associations are often attributed to variation at positions that determine specificity for antigenic peptides, there are other mechanisms by which HLA polymorphism influences the immune response. These include HLA class I interactions with innate immune receptors such as KIR and LILR, cell surface expression levels of HLA class I and class II, and allele-specific variation in HLA dependency on tapasin, a key component of the peptide loading complex. Our studies have identified novel HLA associations in a relatively large number of different types of human disorders, including infectious diseases, cancer, autoimmunity, reproductive diseases, and transplantation outcome.
Recognized as a Fellow of the American Academy of Microbiology in 2021, Dr. Carrington gave the AAI President’s Symposium lecture in 2021 and The Terasaki Lecture BSHI/EFI in Glasgow, UK, in 2021. She was awarded a Visiting Professorship from King’s College, Cambridge University, in Cambridge, the UK in 2018, a Visiting Professorship at Kumamoto University from 2017-2019, and a Newton Abraham Professorship at Oxford University, Oxford, UK, from 2015-2016. Dr. Carrington was awarded the 2009 Rose Payne Award in 2009, the Cecil and Ida Green Visiting Professorship, Green College, the University of British Columbia in 2006, and the Ceppellini Award, from the European Federation for Immunogenetics in 2005.
Dr. Carrington obtained her Ph.D. at Iowa State University in the Immunobiology Department. She performed her postdoctoral studies in the departments of Immunology and Microbiology at Duke University and the University of North Carolina. Prior to her current appointments at the Frederick National Laboratory for Cancer Research, the Laboratory of Integrative Cancer Immunology, National Cancer Institute, and the Ragon Institute.
Ramsuran, V., Naranbhai, V., Horowitz, A., Qi, Y., Martin, M.P., Yuki, Y., Gao, X., Walker-Sperling, V., Del Prete, G.Q., Schneider, D.K., Lifson, J.D., Fellay, J., Deeks, S.G., Martin, J.N., Goedert, J.J., Wolinsky, S.M., Michael, N.L., Kirk, G.D., Buchbinder, S., Haas, D., Ndung’u, T., Goulder, P., Parham, P., Walker, B.D., Carlson, J.M., and Carrington, M.
Science, 359:86-90, PMID: 29302013, 2018
Martin, M.P., Naranbhai, V., Shea, P.R., Qi, Y., Ramsuran, V., Vince, N., Gao, X., Thomas, R., Brumme, Z.L., Carlson, J.M., Wolinsky, S., Goedert, J.J., Walker, B., Segal, F.P., Deeks, S., Haas, D., Migueles, S., Connors, M., Micheal, N., Fellay, J., Price, D.A., Lafont, B.A., Pymm, P., Saunders, P.M., Widjaja, J., Wong, S.C., Vivian, J.P., Rossjohn, J., Brooks, A.G., and Carrington, M.
J. Clin. Invest., PMID: 29461980, 128:1903-1912, 2018
McMichael, A.J. and Carrington, M.
Science, PMID: 31048479, 364:438-439, 2019
Kulkarni, S., Lied, A., Kulkarni, V., Rucevic, M., Ewy, R., Singh, S., McLaren, P.J., Viard, M., Martin, M.P., Naranbhai, V., Zou, C., Lin, Z., Gatanaga, H., Oka, S., Takiguchi, M., Thio, C.L., Margolick, J., Kirk, G.D., Goedert, J.J., Hoots, W.K., Deeks, S.G., Haas, D.W., Michael, N., Walker, B., Le Gall, S., Chowdhury, F., Yu, X.G., and Carrington, M.
Nat. Immunol., PMID: 31209403, 20:824-834, 2019
Niehrs, A., Garcia-Beltran, W.F., Norman, P.J., Watson, G.M., Holzemer, A., Chapel, A., Richert, L., Pommerening-Roser, A., Korner, C., Ozawa, M., Martrus, G., Rossjohn, J., Lee, J-H., Berry, R., Carrington, M., and Altfeld, M.
Nat. Immunol., PMID: 31358998, 20:1129-1137, 2019
Petersdorf, E.W., Stevenson, P., Bengtsson, M., De Santis, D., Dubois, V., Gooley, T., Horowitz, M., Hsu, K., Madrigal, J.A., Malkki, M., McKallor, C., Morishima, Y., Oudshoorn, M., Spellman, S.R., Villard, J., Carrington, M.
Blood, PMID: 32483623, 136:362-369, 2020
Bashirova, A.A., Viard, M., Naranbhai, V., Grifoni, A., Garcia-Beltran, W., Akdag, M., Yuki, Y., Gao, X., O’hUigin, C., Raghavan, M., Wolinsky, S., Bream, J.H., Duggal, P., Martinson, J., Michael, N.L., Kirk, G.D., Buchbinder, S.P., Haas, D., Goedert, J.J., Deeks, S.G., Fellay, J., Walker, B., Goulder, P, Cresswell, P., Elliott, T., Sette, A., Carlson, J. and Carrington, M.
PNAS, PMID: 33097667, 117:28232-28238, 2020
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