Bryan Bryson

Bryan Bryson, PhD

Principal Investigator

Core Member

Ragon Institute of Mass General, MIT, and Harvard

Associate Professor

MIT Department of Biological Engineering

Associate Member

Broad Institute


(617) 258 7641


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Immune control of mycobacteria

Research Overview

The Bryson lab is working to determine how cells of the immune system control and eliminate one of the world’s most deadly pathogens, Mycobacterium tuberculosis (Mtb).

How Mycobacterium tuberculosis is controlled by humans remains a poorly understood process. To address this knowledge gap, our research group combines approaches in microbiology, immunology, and bioengineering to understand and manipulate the complexity of phagocyte state and function in the lung. Paired with these cellular questions, our group develops novel tools to query and perturb the phagosome which we hypothesize contributes to effective Mtb control.


Dr. Bryson received a BS in Mechanical Engineering and PhD in Biological Engineering from MIT. He pursued postdoctoral training at the Harvard TH Chan School of Public Health with Sarah Fortune, where he became fascinated by the complexity of interactions between Mtb and the host. He joined the MIT faculty in 2018 and was promoted to Associate Professor Without Tenure in 2022.

Selected Publications

GM-CSF differentiation of human monocytes stabilizes macrophage state via oxidative signaling

Itoh, C. Y. et al.

bioRxiv 2020.09.29.318352 (2020) doi:10.1101/2020.09.29.318352

Computational Methods for Single-Cell RNA Sequencing

Hie, B. et al.

Annu. Rev. Biomed. Data Sci. 3, 339–364 (2020)

Consensus transcriptional states describe human mononuclear phagocyte diversity in the lung across health and disease

Peters, J. M., Blainey, P. C. & Bryson, B. D.

bioRxiv 2020.08.06.240424 (2020) doi:10.1101/2020.08.06.240424

Single-cell profiling of tuberculosis lung granulomas reveals functional lymphocyte signatures of bacterial control

Gideon, H. P. et al.

bioRxiv 2020.10.24.352492 (2020) doi:10.1101/2020.10.24.352492

Leveraging Uncertainty in Machine Learning Accelerates Biological Discovery and Design

Hie, B., Bryson, B. D. & Berger, B.

Cell Syst. (2020) doi:10.1016/j.cels.2020.09.007

Single Cell and Spatial Transcriptomics Defines the Cellular Architecture of the Antimicrobial Response Network in Human Leprosy Granulomas

Ma, F. et al.

bioRxiv 2020.12.01.406819 (2020) doi:10.1101/2020.12.01.406819

mSphere of Influence: the Complexity of Interferon Gamma-Mediated Pathogen Control

Bryson, B. D.

mSphere 6, (2021)

Learning the language of viral evolution and escape

Hie, B., Zhong, E. D., Berger, B. & Bryson, B.

Science 371, 284–288 (2021)

Lab Team

Akeem Akilimali

Postdoctoral Fellow

Oluremi Akindele

Graduate Student

Ben Allsup

Graduate Student

Diana Gong

Graduate Student

Cal Gunnarson

Graduate Student

Lerato Hlaka

Postdoctoral Fellow

Jacob Hochfelder

Graduate Student

Owen Leddy

Graduate Student

Bianca Lepe

Graduate Student

Amanda Mei

Undergraduate Student

Carlos Mercado-Lara

Undergraduate Student

Josh Peters

Graduate Student

Sydney Solomon

Graduate Student

Kelly Xu

Undergraduate Student

Christine Zheng

Graduate Student

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Leadership: Faculty

The Ragon’s faculty includes many of the world’s most creative scientists, engineers, and clinicians.


The Ragon’s research creates knowledge from our collaborative, cross-disciplinary approach, breaking down the silos of academia.