The Allen Lab explores novel approaches to engineering human immune cells to more effectively target and eliminate HIV and utilizes new gene-editing tools to block the transmission of HIV.
The Allen Lab focuses on translating recent successes in CRISPR gene editing and CAR T cell immunotherapies towards developing a functional cure for HIV. Our work leverages an innovative human stem cell–engrafted mouse model capable of supporting robust HIV infection and developing human immune responses to sHIV. We are also using this model to decipher the host and viral factors influencing the mucosal transmission of HIV.
Dr. Allen is a recipient of the prestigious MGH Scholars Award. He has also been named as a Thomas Reuters Highly Cited Researcher in 2015 and 2016, ranking among the top 1% of researchers in Microbiology.
Dr. Todd Allen received his Ph.D. in Cellular & Molecular Biology from the University of Wisconsin before joining the Ragon Institute in 2001. He received his undergraduate degree in biochemistry from the University of Waterloo in Ontario, Canada. He is also an Associate Member of the Broad Institute of MIT and Harvard.
Allen, T.M., O’Connor, D.H., Mothé, B.R., Vogel, T.U., Liebl, M.E., Jing, P., Dzuris, J.L., Emerson, C., Kunstman, K.J., Wang, X., Desrosiers, R.C., Altman, J.D., Wolinsky, S.M., Sette, A., and Watkins, D.I.
Nature 2000 407(6802):386-390
O’Connor, D.H.*, Allen, T.M.*, Vogel, T.U., Jing, P., DeSouza, I., Dunphy, E., Melsaether, C., Dodds, E., Mothe, B., Horton, H., and Watkins, D.I.
Nature Medicine 2002 8(5) 493-499
Altfeld, M.*, Allen, T.M.*, Yu, X.G., Johnston, M.N., Agrawal, D., Korber, B.T., Montefiori, D.C., O’Connor, D.H., Davis, B.T., Lee, P.K., Maier, E.L., Harlow, J., Goulder, P.J.R., Brander, C., Rosenberg, E.S., and Walker, B.D.
Nature 2002 420(6914):434-9
Timm, J., Lauer, G.M., Kavanagh, D.G., Sheridan, I., Kim, A.Y., Lucas, M., Pillay, T., Ouchi, K., Reyor, L.L., Zur Wiesch, J.S., Gandhi, R.T., Chung, R.T., Bhardwaj, N., Klenerman, P., Walker, B.D., Allen, T.M.
J. Exp. Med. 2004 Dec 20;200(12):1593-604
Henn MR, Boutwell CL, Charlebois P, Lennon NJ, Power KA, Macalalad AR, Berlin AM, Malboeuf CM, Ryan EM, Gnerre S, Zody MC, Erlich RL, Green LM, Berical A, Wang Y, Casali M, Streeck H, Bloom AK, Dudek T, Tully D, Newman R, Axten KL, Gladden AD, Battis L, Kemper M, Zeng Q, Shea TP, Gujja S, Zedlack C, Gasser O, Brander C, Hess C, Günthard HF, Brumme ZL, Brumme CJ, Bazner S, Rychert J, Tinsley JP, Mayer KH, Rosenberg E, Pereyra F, Levin JZ, Young SK, Jessen H, Altfeld M, Birren BW, Walker BD, Allen TM.
PLoS Pathogens 2012 8(3):e1002529
Dudek TE, No DC, Seung E, Vrbanac VD, Fadda L, Bhoumik P, Boutwell CL, Power KA, Gladden AD, Battis L, Mellors EF, Tivey TR, Gao X, Altfeld M, Luster AD, Tager AM, and Allen TM.
Science Translational Medicine. 2012 Jul 18;4(143):143ra98
Joshi VR, Newman RM, Pack ML, Power KA, Munro JB, Okawa K, Madani N, Sodroski JG, Schmidt AG, Allen TM.
PLoS Pathogens. 2020 May 11;16(5). PMID: 32392227
Maldini CR, Claiborne DT, Okawa K, Chen T, Dopkin DL, Shan X, Power KA, Trifonova RT, Krupp K, Phelps M, Vrbanac VD, Tanno S, Bateson T, Leslie GJ, Hoxie JA, Boutwell CL, Riley JL, Allen TM.
Nature Medicine. 2020 Aug 31
Senior Research Scientist
Senior Lab Manager
Our people are our greatest asset. We are committed to creating a supportive and inclusive environment that is welcoming for all.READ MORE
The Ragon’s faculty includes many of the world’s most creative scientists, engineers, and clinicians.READ MORE